J Dent Res. 2005 Feb;84(2):160-5.

Sex-related differences in gene expression in salivary glands of BALB/c mice.

Treister NS, Richards SM, Lombardi MJ, Rowley P, Jensen RV, Sullivan DA.

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Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02114, USA. ntreister@partners.org

Abstract

Sex-related differences exist in the structure and function of the major glands in a variety of species. Moreover, many of these variations appear to be unique to each tissue. We hypothesized that this sexual dimorphism is due, at least in part, to gland-specific differences in gene expression between males and females. Glands were collected from male and female BALB/c mice (n = 5/sex/experiment), and total RNA was isolated. Samples were analyzed for differentially expressed mRNAs with CodeLink microarrays, and data were evaluated by GeneSifter. Our results demonstrate that significant (P < 0.05) sex-related differences exist in the expression of numerous genes in the major salivary glands, and many of these differences were tissue-specific. These findings support our hypothesis that sex-related differences in the salivary glands are due, at least in part, to tissue-specific variations in gene expression.

PMID:: 15668334; [PubMed - indexed for MEDLINE]

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