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Curr Biol. 2005 Jan 26;15(2):R64-7.

beta-Catenin: a pivot between cell adhesion and Wnt signalling.

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  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH UK.


Mutual adhesion of animal cells is intimately linked to Wnt signaling through a shared component: beta-catenin, or Armadillo in Drosophila. Recent work indicates how beta-catenin shifts from cell adhesion to Wnt signaling, a switch associated with epithelial-mesenchymal transitions and cancer.

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