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Nat Neurosci. 2005 Feb;8(2):137-9. Epub 2005 Jan 23.

The site of action potential initiation in cerebellar Purkinje neurons.

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  • 1Wolfson Institute for Biomedical Research, Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK.


Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.

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