Pediatr Infect Dis J. 2005 Jan;24(1):85-6.

Reduced immunogenicity of diphtheria and tetanus toxoids when combined with pertussis toxoid.

Trollfors B, Taranger J, Lagergård T, Sundh V.

Source

Department of Pediatrics, Sahlgrenska University Hospital and Göteborg University, Göteborg, Sweden.

Abstract

The effect of pertussis toxoid on the immunogenicity of diphtheria and tetanus toxoids (DT) was studied during a double blind efficacy trial of an acellular pertussis vaccine. Infants received DT with or without pertussis toxoid at 3, 5 and 12 months of age. Geometric mean concentrations were higher in the DT than in the DT-pertussis toxoid group 1 month (diphtheria toxoid 4.76 versus 3.58 IU/mL, P = 0.009; tetanus toxoid 4.42 versus 2.66 IU/mL, P < 0.0001) and 2 years after the third injection (diphtheria toxoid 0.15 versus 0.10 IU/mL, P < 0.0001; tetanus toxoid 0.38 versus 0.18 IU/mL, P < 0.0001). Pertussis toxoid causes a small but significant reduction of the immunogenicity of diphtheria toxoid and tetanus toxoid.

PMID:: 15665717; [PubMed - indexed for MEDLINE]

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