Nature. 2005 Jan 20;433(7023):E6; discussion E7-8.

Evolutionary genomics: detecting selection needs comparative data.

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Centre for Bioinformatics, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark. rasmus@binf.ku.dk

Abstract

Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al. describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.

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Nature. 2004 Apr 29;428(6986):942-5.

PMID:: 15662372; [PubMed - indexed for MEDLINE]

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Evolutionary genomics: codon volatility does not detect selection. [Nature. 2005]
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Cited by 2 PubMed Central articles

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