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Curr Opin Genet Dev. 2005 Feb;15(1):77-86.

Targeting key steps in metastatic tumour progression.

Author information

  • 1Tumour Biology and Metastasis, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, McElwain Laboratories, Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, UK. sue.eccles@icr.ac.uk

Abstract

The key determinants of tumour progression and discriminators of benign and malignant lesions include neoangiogenesis (the induction of a new blood supply) and the capacity of malignant cells to invade and metastasise. It is now recognized that these processes can be co-ordinately regulated by the activity of specific genes -- often distinct from those involved in early oncogenesis -- and involve common signalling pathways. Cell motility and chemotaxis (the ability to respond to gradients of chemoattractants) are implicated in both tumour-cell invasion and response of activated endothelial cells to angiogenic cytokines, and provide interesting and novel points for therapeutic intervention.

PMID:
15661537
[PubMed - indexed for MEDLINE]
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