Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Geriatr Psychiatry. 2005 Feb;20(2):128-36.

Object naming and semantic fluency among individuals with genetic risk for Alzheimer's disease.

Author information

  • 1Department of Psychiatry and Biobehavioral Sciences, the Neuropsychiatric Institute, the Alzheimer's Disease Center, and the Center on Aging, University of California at Los Angeles, Los Angeles 90024-1759, USA. kmiller@mednet.ucla.edu

Abstract

OBJECTIVES:

This study longitudinally examined the object naming and semantic fluency of individuals who are at risk for developing Alzheimer's disease (AD) by virtue of having APOE-4 or a family history of AD.

METHODS:

A total of 108 participants (40 with a family history of AD and 43 with APOE-4) completed the Boston Naming Test and the Animal Naming task at initial assessment and after two years.

RESULTS:

At baseline, object naming was significantly lower for those with both risk factors, F(2, 99) = 5.72, p < 0.01, but those with either risk factor had significantly lower scores at follow-up, F(2, 99) = 3.41, p < 0.05. Semantic fluency (animal naming) was reduced among subjects with the APOE-4 allele at baseline, F(1, 100) = 4.02, p < 0.05, but it was not associated with either risk factor at follow-up.

CONCLUSIONS:

These deficits may be associated with a prodromal risk for AD and may serve as pre-symptomatic markers for the development of AD.

2005 John Wiley & Sons, Ltd.

PMID:
15660408
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk