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Semin Cell Dev Biol. 2005 Feb;16(1):49-58. Epub 2005 Jan 12.

Mechanisms of translational control by the 3' UTR in development and differentiation.

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  • 1Centre for Biochemistry and Cell Biology, School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK. cornelia.demoor@nottingham.ac.uk


Translational control plays a major role in early development, differentiation and the cell cycle. In this review, we focus on the four main mechanisms of translational control by 3' untranslated regions: 1. Cytoplasmic polyadenylation and deadenylation; 2. Recruitment of 4E binding proteins; 3. Regulation of ribosomal subunit binding; 4. Post-initiation repression by microRNAs. Proteins with conserved functions in translational control during development include cytoplasmic polyadenylation element binding proteins (CPEB/Orb), Pumilio, Bruno, Fragile X mental retardation protein and RNA helicases. The translational regulation of the mRNAs encoding cyclin B1, Oskar, Nanos, Male specific lethal 2 (Msl-2), lipoxygenase and Lin-14 is discussed.

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