Oncogene. 1992 Apr;7(4):757-62.

A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein.

Source

Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, South Australia.

Abstract

The murine Cas NS-1 retrovirus carries the v-cbl oncogene and induces pro-B, pre-B and myeloid tumors in mice inoculated at birth. The human homolog of v-cbl is located on chromosome 11q23.3, which is in the region of translocation breakpoints in a range of acute leukemias. The sequencing of the human and murine c-cbl proto-oncogenes has revealed v-cbl as a markedly truncated form of c-cbl that encompasses 40% of the amino terminus. This truncation deletes a proline- and serine/threonine-rich domain and a putative leucine zipper. In this study we describe the nature of a truncated form of c-cbl present in the cutaneous T-cell lymphoma line HUT78. In these cells a genetic rearrangement involving unknown sequences and Alu repeat sequences results in the insertion of a premature stop codon that removes 259 amino acids from the carboxy terminus. This results in the translation of a 72 kDa protein, compared with the 120 kDa protein encoded by full-length c-cbl, which lacks a portion of the proline-rich domain and the entire leucine zipper.

PMID:: 1565471; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Lymphoma - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. [Oncogene. 1991]
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
Blake TJ, Shapiro M, Morse HC 3rd, Langdon WY. Oncogene. 1991 Apr; 6(4):653-7.
The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. [EMBO J. 1993]
The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.
Blake TJ, Heath KG, Langdon WY. EMBO J. 1993 May; 12(5):2017-26.
Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia. [Genes Chromosomes Cancer. 2003]
Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia.
Fu JF, Hsu JJ, Tang TC, Shih LY. Genes Chromosomes Cancer. 2003 Jun; 37(2):214-9.
Review The Cbl family of signal transduction molecules. [Crit Rev Oncog. 1997]
Review The Cbl family of signal transduction molecules.
Smit L, Borst J. Crit Rev Oncog. 1997; 8(4):359-79.
Review The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. [Crit Rev Oncog. 1997]
Review The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction.
Miyake S, Lupher ML Jr, Andoniou CE, Lill NL, Ota S, Douillard P, Rao N, Band H. Crit Rev Oncog. 1997; 8(2-3):189-218.

See reviews... See all...

Cited by 7 PubMed Central articles

Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights. [Protein Sci. 2008]
Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights.
Zhou ZR, Gao HC, Zhou CJ, Chang YG, Hong J, Song AX, Lin DH, Hu HY. Protein Sci. 2008 Oct; 17(10):1805-14. Epub 2008 Jul 2.
Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. [Blood. 2007]
Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.
Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, Arnoczky KJ, Marburger TB, Wen J, Perrotti D, Bloomfield CD, et al. Blood. 2007 Aug 1; 110(3):1022-4. Epub 2007 May 2.
Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype. [BMC Genet. 2001]
Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype.
Calin G, Ranzani GN, Amadori D, Herlea V, Matei I, Barbanti-Brodano G, Negrini M. BMC Genet. 2001; 2:14. Epub 2001 Aug 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in...
A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein.
Oncogene. 1992 Apr ;7(4):757-62.

PubMed
Interventions used to improve control of blood pressure in patients with hyperte...
Interventions used to improve control of blood pressure in patients with hypertension.
Cochrane Database Syst Rev. 2005 Jan 25 ;(1):CD005182.

PubMed
Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a de...
Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in the BBS4 gene.
Am J Med Genet A. 2005 Feb 1 ;132(4):343-6.

PubMed
Factors predictive of corneal graft survival. Report from the Australian Corneal...
Factors predictive of corneal graft survival. Report from the Australian Corneal Graft Registry.
Ophthalmology. 1992 Mar ;99(3):403-14.

PubMed
Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-medi...
Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans.
Inflamm Res. 2004 Dec ;53(12):680-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A rearrangement of the c-cbl proto-oncogene in HUT78 T-lymphoma cells results in a truncated protein.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information