Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line

Elena Bayer; Michael Thutewohl; Claudia Christner; Thomas Tradler; Frank Osterkamp; Herbert Waldmann; Peter Bayer

doi:10.1039/b414037k

Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line

Chem Commun (Camb). 2005 Jan 28:(4):516-8. doi: 10.1039/b414037k. Epub 2004 Dec 6.

Authors

Elena Bayer¹, Michael Thutewohl, Claudia Christner, Thomas Tradler, Frank Osterkamp, Herbert Waldmann, Peter Bayer

Affiliation

¹ Molecular and Structural Biophysics, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.

PMID: 15654388
DOI: 10.1039/b414037k

Abstract

The authors have developed a class of potent inhibitors against the phosphate specific prolyl isomerase hPin1, which induced apoptosis in transformed cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects*
Cell Line
Cell Transformation, Neoplastic / drug effects*
Enzyme Inhibitors* / chemical synthesis
Enzyme Inhibitors* / chemistry
Enzyme Inhibitors* / pharmacology
Humans
Molecular Structure
NIMA-Interacting Peptidylprolyl Isomerase
Peptidylprolyl Isomerase / antagonists & inhibitors*
ras Proteins / metabolism*

Substances

Enzyme Inhibitors
NIMA-Interacting Peptidylprolyl Isomerase
ras Proteins
PIN1 protein, human
Peptidylprolyl Isomerase