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Nat Rev Mol Cell Biol. 2005 Feb;6(2):99-111.

Reconstruction of cellular signalling networks and analysis of their properties.

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  • 1Department of Bioengineering, 9500 Gilman Drive, Mail Code 0412, University of California, San Diego, La Jolla, California 92093-0412, USA.

Abstract

The study of cellular signalling over the past 20 years and the advent of high-throughput technologies are enabling the reconstruction of large-scale signalling networks. After careful reconstruction of signalling networks, their properties must be described within an integrative framework that accounts for the complexity of the cellular signalling network and that is amenable to quantitative modelling.

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