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Physiology (Bethesda). 2005 Feb;20:70-8.

Neurotrophin-mediated rapid signaling in the central nervous system: mechanisms and functions.

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  • 1Institut für Physiologie, Ludwig-Maximilians-Universität München, Germany.


Neurotrophins regulate growth, survival, and differentiation of central neurons. In addition to the "classical" effects that are relatively slow neurotrophins also elicit rapid signaling that modulates a variety of cellular functions such as membrane excitability, synaptic transmission, and activity-dependent synaptic plasticity. These rapid actions are mediated mainly through the interaction of Trk receptors with ion channels and ionotropic receptors in the plasma membrane.

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