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    Vascul Pharmacol. 2004 Jul;41(6):187-95.

    Peroxisome proliferator-activated receptors gamma ligands and ischemia and reperfusion injury.

    Cuzzocrea S.

    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, via C. Valeria, Torre Biologica, Policlinico Universitario, 98123 Messina, Italy. salvator@unime.it

    Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. PPAR-gamma has recently been implicated as a regulator of cellular proliferation and inflammatory responses. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR-gamma ligands in ischemia and reperfusion will be discussed in this review.

    PMID: 15653094 [PubMed - indexed for MEDLINE]

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