Cell. 2005 Jan 14;120(1):1-2.

Alternative splicing regulation impacts heart development.

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Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

SR proteins serve multiple roles in the posttranscriptional control of gene expression, including as regulators of alternative splicing. In this issue of Cell, Xu et al. (2005) demonstrate that a heart-specific knockout of one SR protein, ASF/SF2, produces cardiomyopathy and misregulation of specific alternative splicing events during early postnatal development.

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Cell. 2005 Jan 14;120(1):59-72.

PMID:: 15652472; [PubMed - indexed for MEDLINE]

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