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Semin Cancer Biol. 2005 Apr;15(2):113-20.

Expanding fields of genetically altered cells in head and neck squamous carcinogenesis.

Author information

  • 1Section Tumorbiology, Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. bjm.braakhuis@vumc.nl

Abstract

Recent molecular pathology studies in head and neck cancer support a carcinogenesis model in which the development of a field with genetically altered cells plays a central role. This preneoplastic field is of monoclonal origin and expands non-invasively superseding normal epithelium. Clonal divergence and selection within the field ultimately leads to the development of cancer. These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may remain after resection of the primary tumor. When not removed, a field is an important risk factor for secondary cancer.

PMID:
15652456
[PubMed - indexed for MEDLINE]
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