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J Am Chem Soc. 2005 Jan 19;127(2):547-53.

Chain-length-dependent helical motifs and self-association of beta-peptides with constrained side chains.

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  • 1Institute of Pharmaceutical Chemistry and Department of Medical Chemistry, University of Szeged, P.O. Box 121, H-6701 Szeged, Hungary.


Homo-oligomers constructed by using trans-2-aminocyclohexanecarboxylic acid monomers without protecting groups were studied. Both ab initio theory and NMR measurements showed that the tetramer tends to adopt a 10-helix motif, while the pentamer and hexamer form the known 14-helix. It was concluded that the conformationally constrained backbone is flexible enough to afford both 10-helical and 14-helical motifs, this observation in turn providing evidence of the true folding process. Self-association of the helical units was also detected, and the results of variable-temperature diffusion NMR measurements strongly suggested the presence of helical bundles in methanol solution.

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