Nat Neurosci. 2005 Feb;8(2):147-8. Epub 2005 Jan 9.

Pathological gambling is linked to reduced activation of the mesolimbic reward system.

Reuter J, Raedler T, Rose M, Hand I, Gläscher J, Büchel C.

Source

NeuroImage Nord, Department of Neurology, Hamburg University Hospital Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

Abstract

By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.

PMID:: 15643429; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Compulsive Gambling - MedlinePlus Health Information

Molecular Biology Databases

OXYGEN - HSDB

Supplemental Content

Related citations

Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of "super normal controls" in psychiatricgenetic research of complex behavioral disorders. [Med Hypotheses. 2005]
Are dopaminergic genes involved in a predisposition to pathological aggression? Hypothesizing the importance of "super normal controls" in psychiatricgenetic research of complex behavioral disorders.
Chen TJ, Blum K, Mathews D, Fisher L, Schnautz N, Braverman ER, Schoolfield J, Downs BW, Comings DE. Med Hypotheses. 2005; 65(4):703-7.
Cue-induced brain activity in pathological gamblers. [Biol Psychiatry. 2005]
Cue-induced brain activity in pathological gamblers.
Crockford DN, Goodyear B, Edwards J, Quickfall J, el-Guebaly N. Biol Psychiatry. 2005 Nov 15; 58(10):787-95. Epub 2005 Jul 5.
A principal component network analysis of prefrontal-limbic functional magnetic resonance imaging time series in schizophrenia patients and healthy controls. [Psychiatry Res. 2009]
A principal component network analysis of prefrontal-limbic functional magnetic resonance imaging time series in schizophrenia patients and healthy controls.
Rădulescu AR, Mujica-Parodi LR. Psychiatry Res. 2009 Dec 30; 174(3):184-94. Epub 2009 Nov 2.
Review Brain imaging studies in pathological gambling. [Curr Psychiatry Rep. 2010]
Review Brain imaging studies in pathological gambling.
van Holst RJ, van den Brink W, Veltman DJ, Goudriaan AE. Curr Psychiatry Rep. 2010 Oct; 12(5):418-25.
Review Controlled gambling for pathological gamblers. [J Gambl Stud. 2005]
Review Controlled gambling for pathological gamblers.
Ladouceur R. J Gambl Stud. 2005 Spring; 21(1):49-59.

See reviews... See all...

Cited by 33 PubMed Central articles

Reward system and temporal pole contributions to affective evaluation during a first person shooter video game. [BMC Neurosci. 2011]
Reward system and temporal pole contributions to affective evaluation during a first person shooter video game.
Mathiak KA, Klasen M, Weber R, Ackermann H, Shergill SS, Mathiak K. BMC Neurosci. 2011 Jul 12; 12:66. Epub 2011 Jul 12.
Impulse control disorders in Parkinson's disease: clinical characteristics and implications. [Neuropsychiatry (London). 2011]
Impulse control disorders in Parkinson's disease: clinical characteristics and implications.
Leeman RF, Potenza MN. Neuropsychiatry (London). 2011 Apr; 1(2):133-147.
Neuroscience research fails to support claims that excessive pornography consumption causes brain damage. [Surg Neurol Int. 2011]
Neuroscience research fails to support claims that excessive pornography consumption causes brain damage.
Reid RC, Carpenter BN, Fong TW. Surg Neurol Int. 2011; 2:64. Epub 2011 May 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Pathological gambling is linked to reduced activation of the mesolimbic reward s...
Pathological gambling is linked to reduced activation of the mesolimbic reward system.
Nat Neurosci. 2005 Feb ;8(2):147-8. Epub 2005 Jan 9 .

PubMed
Enhanced detection of human immunodeficiency virus type 1-specific T-cell respon...
Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
J Virol. 2003 Jul ;77(13):7330-40.

PubMed
A candidate gene approach to searching for low-penetrance breast and prostate ca...
A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.
Nat Rev Cancer. 2005 Dec ;5(12):977-85.

PubMed
Is weight loss the optimal target for obesity-related cardiovascular disease ris...
Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?
Can J Cardiol. 2008 Sep ;24 Suppl D:25D-31D.

PubMed
The dual origin of the Malagasy in Island Southeast Asia and East Africa: eviden...
The dual origin of the Malagasy in Island Southeast Asia and East Africa: evidence from maternal and paternal lineages.
Am J Hum Genet. 2005 May ;76(5):894-901. Epub 2005 Mar 25 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Pathological gambling is linked to reduced activation of the mesolimbic reward system.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 33 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information