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Genome Biol. 2005;6(1):R8. Epub 2004 Dec 20.

Using ontologies to describe mouse phenotypes.

Author information

  • 1Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK. g.gkoutos@har.mrc.ac.uk

Abstract

The mouse is an important model of human genetic disease. Describing phenotypes of mutant mice in a standard, structured manner that will facilitate data mining is a major challenge for bioinformatics. Here we describe a novel, compositional approach to this problem which combines core ontologies from a variety of sources. This produces a framework with greater flexibility, power and economy than previous approaches. We discuss some of the issues this approach raises.

PMID:
15642100
[PubMed - indexed for MEDLINE]
PMCID:
PMC549069
Free PMC Article

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