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1: Genome Biol. 2005;6(1):R8. Epub 2004 Dec 20.Click here to read Click here to read Links

Using ontologies to describe mouse phenotypes.

Gkoutos GV, Green EC, Mallon AM, Hancock JM, Davidson D.

Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 0RD, UK. g.gkoutos@har.mrc.ac.uk

The mouse is an important model of human genetic disease. Describing phenotypes of mutant mice in a standard, structured manner that will facilitate data mining is a major challenge for bioinformatics. Here we describe a novel, compositional approach to this problem which combines core ontologies from a variety of sources. This produces a framework with greater flexibility, power and economy than previous approaches. We discuss some of the issues this approach raises.

PMID: 15642100 [PubMed - indexed for MEDLINE]

PMCID: PMC549069