Abstract
We report two unrelated patients with infantile spinal muscular atrophy (SMA) types II and IIIa who developed alveolar rhabdomyosarcoma (ARMS) at 15 and 19 years, respectively. The tumours were located in the forearm, within severely atrophic flexor muscles. They displayed a similar histology and shared the most common translocation, t(2;13)(q35;14) in ARMS. Since cell proliferation is increased in de- and regenerating muscle and the PAX3/FKHR fusion protein activates myogenic transcription, it is tempting to speculate whether severe muscle atrophy in SMA might predispose to malignant transformation in long-standing disease.
MeSH terms
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Adolescent
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Cell Proliferation
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Disease Susceptibility*
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Forkhead Box Protein O1
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Forkhead Transcription Factors
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Humans
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Male
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PAX3 Transcription Factor
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Paired Box Transcription Factors
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Rhabdomyosarcoma, Alveolar / etiology*
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Rhabdomyosarcoma, Alveolar / genetics
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Spinal Muscular Atrophies of Childhood / complications*
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Spinal Muscular Atrophies of Childhood / genetics
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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FOXO1 protein, human
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Forkhead Box Protein O1
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Forkhead Transcription Factors
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PAX3 Transcription Factor
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PAX3 protein, human
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Paired Box Transcription Factors
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Transcription Factors