Display Settings:

Format

Send to:

Choose Destination
Cell Stress Chaperones. 2004 Winter;9(4):325-31.

The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.

Author information

  • 1Department of Cell Biology, Duke University Medical Center, Box 3709, Durham, NC 27710, USA. c.nicchitta@cellbio.duke.edu

Abstract

Vaccination of mice with tumor-derived stress proteins, such as Hsp70 and gp96 (GRP94), can elicit antitumor immune responses, yielding a marked suppression of tumor growth and metastasis. The molecular basis for this response is proposed to reflect a peptide-binding function for these proteins. In this view, stress proteins bind the antigenic peptide repertoire of their parent cell, and when provided to the immune system, tumor-derived stress protein-peptide complexes are processed by antigen-presenting cells (APCs) to yield the subsequent activation of tumor-directed cytotoxic T lymphocyte activity. This model predicts that stress proteins, whose primary intracellular function concerns the proper folding and assembly of nascent polypeptides, intersect with the cellular pathways responsible for the generation, processing, or assembly (or all) of peptide antigens onto nascent major histocompatability class I molecules. Recent insights into the pathways for peptide generation now allow this hypothesis to be critically examined, which is the subject of this review.

PMID:
15633290
[PubMed - indexed for MEDLINE]
PMCID:
PMC1065271
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk