Plasmid. 2005 Jan;53(1):1-13. Epub 2004 Dec 16.

The plasmids of Borrelia burgdorferi: essential genetic elements of a pathogen.

Stewart PE, Byram R, Grimm D, Tilly K, Rosa PA.

Source

Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th St., Hamilton, MT 59840, USA. pestewart@niaid.nih.gov

Abstract

The spirochete Borrelia burgdorferi, the causative agent of Lyme disease, has an unusual genome comprised of a linear chromosome and the largest plasmid complement of any characterized bacterium. Certain plasmid-encoded elements are required for virulence and viability, both in vitro and in vivo. The genetic tools to manipulate B. burgdorferi are sufficiently developed for precise molecular genetic investigations. B. burgdorferi now represents a prime system with which to address basic questions of plasmid biology and plasmid contributions to bacterial virulence and disease pathogenesis.

PMID:: 15631949; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

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Review

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DNA, Circular

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Review The burgeoning molecular genetics of the Lyme disease spirochaete. [Nat Rev Microbiol. 2005]
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Cited by 17 PubMed Central articles

DipA, a Pore-Forming Protein in the Outer Membrane of Lyme Disease Spirochetes Exhibits Specificity for the Permeation of Dicarboxylates. [PLoS One. 2012]
DipA, a Pore-Forming Protein in the Outer Membrane of Lyme Disease Spirochetes Exhibits Specificity for the Permeation of Dicarboxylates.
Thein M, Bonde M, Bunikis I, Denker K, Sickmann A, Bergström S, Benz R. PLoS One. 2012; 7(5):e36523. Epub 2012 May 10.
Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids. [PLoS One. 2012]
Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids.
Casjens SR, Mongodin EF, Qiu WG, Luft BJ, Schutzer SE, Gilcrease EB, Huang WM, Vujadinovic M, Aron JK, Vargas LC, et al. PLoS One. 2012; 7(3):e33280. Epub 2012 Mar 14.
Borrelia burgdorferi linear plasmid 38 is dispensable for completion of the mouse-tick infectious cycle. [Infect Immun. 2011]
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Dulebohn DP, Bestor A, Rego RO, Stewart PE, Rosa PA. Infect Immun. 2011 Sep; 79(9):3510-7. Epub 2011 Jun 27.

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