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J Clin Invest. 2005 Jan;115(1):20-3.

A new mechanism of BRAF activation in human thyroid papillary carcinomas.

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  • 1Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolt√† di Medicina e Chirurgia di Napoli, Universit√† degli Studi di Napoli Federico II, Naples, Italy. afusco@napoli.com

Abstract

In this issue of the JCI, Ciampi et al. report the identification of a novel oncogene in patients affected by radiation-associated thyroid papillary carcinomas. This oncogene derives from a paracentric inversion of the long arm of chromosome 7, which results in an in-frame fusion of the N-terminus of the A-kinase anchor protein 9 (AKAP9) gene with the C-terminal catalytic domain (exons 9-18) of the serine-threonine kinase BRAF. The resulting AKAP9-BRAF fusion protein shows constitutive kinase activity, and it is able to transmit mitogenic signals to the MAPK pathways and to promote malignant transformation of NIH3T3 cells.

PMID:
15630436
[PubMed - indexed for MEDLINE]
PMCID:
PMC539208
Free PMC Article
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