In mammal lungs different compartments for leukocytes can be identified during health and disease, e.g. lung interstitium, bronchoalveolar space, the epithelium and lamina propria of the air-conducting part. A so far neglected compartment is the space around the branches of the pulmonary arteries, characterized by a unique architecture of capillaries running in parallel to the pulmonary artery. This compartment - the periarterial space - is described and its physiological and pathophysiological role reviewed. The periarterial space is infiltrated by different leukocyte subsets during edema formation in the early stages of a lung transplant rejection and, in particular, during inflammatory and allergic reactions. The periarterial compartment seems to be of major relevance in all these situations. Copyright 2004 S. Karger AG, Basel.