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Biochim Biophys Acta. 2005 Jan 11;1681(2-3):175-81. Epub 2004 Nov 26.

Transcriptional regulation of the mouse microtubule-associated protein tau.

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  • 1Shriver Center for Mental Retardation, Waltham, MA 02452, USA.


The microtubule-associated protein (MAP) tau is found primarily in neurons and errors in its regulation are associated with Alzheimer's disease and other neurodegenerative disorders. Tau expression is transcriptionally regulated and tissue-specific. In this study, starting with a approximately 7500-bp fragment from the mouse tau gene, which includes tau exon -1, we define regions preferentially conferring tissue-specific expression. Furthermore, gel shift assays indicate that transcriptional regulators SP-1 and AP-2 are important for basal expression but not necessary for neuron-specific expression of the tau transcript.

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