Exp Toxicol Pathol. 2004 Dec;56(3):195-201.

Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats.

Valcheva-Kuzmanova S, Borisova P, Galunska B, Krasnaliev I, Belcheva A.

Source

Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 9002 Varna, Bulgaria. stefkavk@yahoo.com

Abstract

The fruits of Aronia melanocarpa are rich in anthocyanins--plant pigments with anti-inflammatory and antioxidant activity. We studied the effect of the natural fruit juice from A. melanocarpa (NFJAM) on carbon tetrachloride (CCl4)-induced acute liver damage in rats. Histopathological changes such as necrosis, fatty change, ballooning degeneration and inflammatory infiltration of lymphocytes around the central veins occurred in rats following acute exposure to CCl4 (0.2 ml kg(-1), 2 days). The administration of CCl4 increased plasma aspartate transaminase (AST) and alanine transaminase (ALT) activities, induced lipid peroxidation (as measured by malondialdehyde (MDA) content in rat liver and plasma) and caused a depletion of liver reduced glutathione (GSH). NFJAM (5, 10 and 20 ml kg(-1), 4 days) dose-dependently reduced the necrotic changes in rat liver and inhibited the increase of plasma AST and ALT activities, induced by CCl4 (0.2ml kg(-1), 3rd and 4th days). NFJAM also prevented the CCl4-induced elevation of MDA formation and depletion of GSH content in rat liver.

PMID:: 15625789; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Protective effect of Aronia melanocarpa fruit juice pretreatment in a model of carbon tetrachloride-induced hepatotoxicity in rats. [Folia Med (Plovdiv). 2006]
Protective effect of Aronia melanocarpa fruit juice pretreatment in a model of carbon tetrachloride-induced hepatotoxicity in rats.
Valcheva-Kuzmanova SV, Popova PB, Galunska BT, Belcheva A. Folia Med (Plovdiv). 2006; 48(2):57-62.
Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats. [Exp Toxicol Pathol. 2005]
Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats.
Valcheva-Kuzmanova S, Marazova K, Krasnaliev I, Galunska B, Borisova P, Belcheva A. Exp Toxicol Pathol. 2005 Apr; 56(6):385-92.
Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. [J Ethnopharmacol. 2008]
Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats.
Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C. J Ethnopharmacol. 2008 May 8; 117(2):300-8. Epub 2008 Feb 14.
Review Current knowledge of Aronia melanocarpa as a medicinal plant. [Folia Med (Plovdiv). 2006]
Review Current knowledge of Aronia melanocarpa as a medicinal plant.
Valcheva-Kuzmanova SV, Belcheva A. Folia Med (Plovdiv). 2006; 48(2):11-7.
Review Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. [Crit Rev Toxicol. 2003]
Review Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model.
Weber LW, Boll M, Stampfl A. Crit Rev Toxicol. 2003; 33(2):105-36.

See reviews... See all...

Cited by 1 PubMed Central article

Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion. [BMC Complement Altern Med. 2011]
Antioxidative protection of dietary bilberry, chokeberry and Lactobacillus plantarum HEAL19 in mice subjected to intestinal oxidative stress by ischemia-reperfusion.
Jakesevic M, Aaby K, Borge GI, Jeppsson B, Ahrné S, Molin G. BMC Complement Altern Med. 2011 Jan 27; 11:8. Epub 2011 Jan 27.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on ca...
Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats.
Exp Toxicol Pathol. 2004 Dec ;56(3):195-201.

PubMed
Expression of Sox8, Sf1, Gata4, Wt1, Dax1, and Fog2 in the mouse ovarian follicl...
Expression of Sox8, Sf1, Gata4, Wt1, Dax1, and Fog2 in the mouse ovarian follicle: implications for the regulation of Amh expression.
Mol Reprod Dev. 2005 Mar ;70(3):271-7.

PubMed
A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment o...
A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis.
Clin Gastroenterol Hepatol. 2004 Dec ;2(12):1107-15.

PubMed
Thoracolumbar fractures associated with the use of personal watercraft.
Thoracolumbar fractures associated with the use of personal watercraft.
J Trauma. 2004 Dec ;57(6):1308-10.

PubMed
Suspended animation can allow survival without brain damage after traumatic exsa...
Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs.
J Trauma. 2004 Dec ;57(6):1266-75.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information