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Leuk Lymphoma. 2004 Dec;45(12):2497-501.

Imatinib-responsive hypereosinophilia in a patient with B cell ALL.

Author information

  • 1Hematology Branch, National Heart Lung and Blood Institute National Institutes of Health Bethesda, MD 20892, USA. robynj@nih.gov


Hypereosinophilia is a rare presenting sign of acute lymphocytic leukemia. A 29-year-old male was diagnosed with idiopathic hypereosinophilic syndrome with respiratory symptoms. Although his peripheral blood eosinophilia decreased in response to treatment with imatinib mesylate, a follow-up bone marrow showed a diffuse infiltrate of myeloperoxidase-negative blasts. He was subsequently diagnosed with CD10 positive precursor B lymphoblastic leukemia. This case underscores the importance of follow-up bone marrow examination in patients who demonstrate imatinib mesylate-responsive eosinophilia.

[PubMed - indexed for MEDLINE]
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