Human interferons alpha, beta and omega. [Growth Factors. 2004]

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1: Growth Factors. 2004 Dec;22(4):243-51. Links

Human interferons alpha, beta and omega.

Bekisz J, Schmeisser H, Hernandez J, Goldman ND, Zoon KC.

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.

PMID: 15621727 [PubMed - indexed for MEDLINE]

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