DNA Seq. 2004 Aug;15(4):303-5.

Cloning and analysis of human Apg16L.

Zheng H, Ji C, Li J, Jiang H, Ren M, Lu Q, Gu S, Mao Y, Xie Y.

Source

State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.

Abstract

Autophagy is an intracellular bulk degradation system, which delivers cytoplasmic components to the lysosome/vacuole. In yeast and mammalian cells, the Apg12-Apg5 conjugate, together with Apg16, form a multimeric complex, which plays an essential role in autopihageosome formation. By large-scale sequencing analysis of a human fetal brain cDNA library, we isolated a cDNA encoding a putative protein with 607 amino acid residues, which shows 90% identity and 93% similarity to mouse Apg16L. This protein, designated human Apg16L, contains a coiled-coil domain and a motif with seven WD repeats, which are also shared by mouse Apg16L. Database searching revealed that Apg16L is mapped to chromosome 2q37.1 and there exist at least four splice variants.

PMID:: 15620219; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances, Secondary Source ID

MeSH Terms

Substances

Protein Isoforms

Secondary Source ID

GENBANK/AY398617

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Medical

ATG16L1 Gene - Genetics Home Reference

Research Materials

anti-ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1) antibody - antibodies-online

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Related citations in PubMed

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. [J Cell Sci. 2003]
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.
Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, Natsume T, Ohsumi Y, Yoshimori T. J Cell Sci. 2003 May 1; 116(Pt 9):1679-88.
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. [J Biol Chem. 2002]
Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast.
Kuma A, Mizushima N, Ishihara N, Ohsumi Y. J Biol Chem. 2002 May 24; 277(21):18619-25. Epub 2002 Mar 15.
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy. [J Biol Chem. 1998]
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.
Mizushima N, Sugita H, Yoshimori T, Ohsumi Y. J Biol Chem. 1998 Dec 18; 273(51):33889-92.
A protein conjugation system essential for autophagy. [Nature. 1998]
A protein conjugation system essential for autophagy.
Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD, Klionsky DJ, Ohsumi M, Ohsumi Y. Nature. 1998 Sep 24; 395(6700):395-8.
Review Role of the Apg12 conjugation system in mammalian autophagy. [Int J Biochem Cell Biol. 2003]
Review Role of the Apg12 conjugation system in mammalian autophagy.
Mizushima N, Yoshimori T, Ohsumi Y. Int J Biochem Cell Biol. 2003 May; 35(5):553-61.

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Cited by 3 PubMed Central articles

Three isoforms of the Atg16L1 protein contribute different autophagic properties. [Mol Cell Biochem. 2013]
Three isoforms of the Atg16L1 protein contribute different autophagic properties.
Jiang T, Qin B, He J, Lin S, Ding S. Mol Cell Biochem. 2013 Jun; 378(1-2):257-66. Epub 2013 Mar 20.
Review Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. [Curr Mol Med. 2010]
Review Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer.
Brest P, Corcelle EA, Cesaro A, Chargui A, Belaïd A, Klionsky DJ, Vouret-Craviari V, Hebuterne X, Hofman P, Mograbi B. Curr Mol Med. 2010 Jul; 10(5):486-502.
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. [PLoS One. 2008]
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.
Kuballa P, Huett A, Rioux JD, Daly MJ, Xavier RJ. PLoS One. 2008; 3(10):e3391. Epub 2008 Oct 13.

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