Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2005 Jan 19;16(1):39-43.

Combination of high fat diet and chronic stress retracts hippocampal dendrites.

Author information

  • 1Department of Psychology, Arizona State University, Tempe, AZ 85287-1104, USA.

Abstract

Adult male rats were fed a low or high fat diet and given psychosocial stress (crowded and unstable housing with daily predator exposure) for 3 weeks. Neither stress nor high fat diet, alone, produced dendritic atrophy; only the group given the combination of stress and high fat diet developed a reduction of the length and number of branch points of apical dendrites of CA3 neurons. These findings indicate that a synergy between high fat diet and stress caused a retraction of CA3 dendrites. The findings are consistent with work on peripheral (e.g., cardiovascular) systems demonstrating a synergy between stress and high fat diet, and are relevant toward understanding how diet and stress interact to adversely affect brain and memory processing.

PMID:
15618887
[PubMed - indexed for MEDLINE]
PMCID:
PMC1363787
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk