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    Brain Res Dev Brain Res. 2005 Jan 1;154(1):57-62.

    Fetal magnetoencephalography--a multimodal approach.

    Eswaran H, Lowery CL, Wilson JD, Murphy P, Preissl H.

    Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, 4301 W. Markham, Slot 518, Little Rock, Arkansas 72205, USA. eswaranhari@uams.edu

    Past studies have shown the feasibility of recording fetal evoked responses to external stimuli using a non-invasive technique called magnetoencephalography (MEG). These studies were all performed using either auditory or visual stimuli and showed a fairly low detection rate for each modality, thus making this technology currently unreliable for fetal clinical applications. This study is based on the hypothesis that a multimodal approach of applying both auditory and visual stimulation paradigms in successive recording sessions could improve the probability of obtaining a fetal evoked response. A total of 34 studies were performed on 11 normal healthy fetuses at different stages of gestation starting as early as 28 weeks with a 151-channel fetal MEG system. The success rate of obtaining a response to either (or both) stimuli from a study at a given gestation age was 91%. All the 11 fetuses showed a response at least once over the gestation period the recordings were performed. A multimodal testing approach can improve the ability of the MEG technique to reliably monitor the functional development of the fetal brain.

    PMID: 15617755 [PubMed - indexed for MEDLINE]

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