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Bioinformatics. 2005 Apr 15;21(8):1739-40. Epub 2004 Dec 21.

Expa: a program for calculating extreme pathways in biochemical reaction networks.

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  • 1Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.


The set of extreme pathways, a generating set for all possible steady-state flux maps in a biochemical reaction network, can be computed from the stoichiometric matrix, an incidence-like matrix reflecting the network topology. Here, we describe the implementation of a well-known algorithm to compute these pathways and give a summary of the features of the available software.


The C-code, along with a Windows executable and sample network reaction files, are available at


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