Psychiatry Res. 1992 Jan;41(1):1-8.

Prodromal symptoms and signs of bipolar relapse: a report based on prospectively collected data.

Altman ES, Rea MM, Mintz J, Miklowitz DJ, Goldstein MJ, Hwang S.

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Department of Psychology, University of California, Los Angeles 90024-1563.

Abstract

Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.

PMID:: 1561285; [PubMed - indexed for MEDLINE]

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