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Nature. 1992 Apr 9;356(6369):494-9.

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death.

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  • 1Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.


The gene ced-9 of the nematode Caenorhabditis elegans acts to protect cells from programmed cell death. A mutation that abnormally activates ced-9 prevents the cell deaths that occur during normal C. elegans development. Conversely, mutations that inactivate ced-9 cause cells that normally live to undergo programmed cell death; these mutations result in embryonic lethality, indicating that ced-9 function is essential for development. The ced-9 gene functions by negatively regulating the activities of other genes that are required for the process of programmed cell death.

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