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Mol Immunol. 2005 Feb;42(4):477-84.

Coordination of activating and inhibitory signals in natural killer cells.

Author information

  • 1Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS-Université de la Méditerranée, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France.

Erratum in

  • Mol Immunol. 2005 Apr;42(6):743-6.


NK cells are equipped with multiple activating and inhibitory cell surface receptors whose engagement regulate NK cell effector function (i.e. cytotoxicity as well as chemokine and cytokine production). Several components (adaptors, effector molecules) that participate to NK cell signalling pathways have been described. Yet, the spatio-temporal organisation of these pathways is still poorly understood. In addition, the mechanisms that integrate several simultaneous input signals in NK cells remain to be elucidated.

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