bHLH transcription factor Olig1 is required to rep...[Science. 2004]

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1: Science. 2004 Dec 17;306(5704):2111-5. Links

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.

Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.

PMID: 15604411 [PubMed - indexed for MEDLINE]

Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice.
J Neurosci. 2005 Feb 9; 25(6):1354-65.

[J Neurosci. 2005]
Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.
Mech Dev. 2000 Dec; 99(1-2):143-8.

[Mech Dev. 2000]
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.
Cell. 2002 Apr 5; 109(1):61-73.

[Cell. 2002]
ReviewOlig gene function in CNS development and disease.
Glia. 2006 Jul; 54(1):1-10.

[Glia. 2006]
ReviewRegulation of oligodendrocyte development.
Microsc Res Tech. 2001 Mar 15; 52(6):740-5.

[Microsc Res Tech. 2001]
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[Genes Dev. 2009]
Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.
Nakahara J, Kanekura K, Nawa M, Aiso S, Suzuki N. J Clin Invest. 2009 Jan; 119(1):169-81. Epub 2008 Dec 22.

[J Clin Invest. 2009]
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.
Lecca D, Trincavelli ML, Gelosa P, Sironi L, Ciana P, Fumagalli M, Villa G, Verderio C, Grumelli C, Guerrini U, et al. PLoS One. 2008; 3(10):e3579. Epub 2008 Oct 31.

[PLoS One. 2008]
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