Pyrimidine containing RSV fusion inhibitors. [Bioorg Med Chem Lett. 2005]

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1: Bioorg Med Chem Lett. 2005 Jan 17;15(2):427-30. Links

Pyrimidine containing RSV fusion inhibitors.

Nikitenko A, Raifeld Y, Mitsner B, Newman H.

Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. nikitea@wyeth.com

The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs.

PMID: 15603966 [PubMed - indexed for MEDLINE]

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Pyrimidine containing RSV fusion inhibitors.

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