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Hum Genomics. 2004 Jan;1(2):87-97.

Robustness of the inference of human population structure: a comparison of X-chromosomal and autosomal microsatellites.

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  • 1Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

Abstract

In this paper, data on 20 X-chromosomal microsatellite polymorphisms from the HGDP-CEPH cell line panel are used to infer human population structure. Inferences from these data are compared to those obtained from autosomal microsatellites. Some of the major features of the structure seen with 377 autosomal markers are generally visible with the X-linked markers, although the latter provide less resolution. Differences between the X-chromosomal and autosomal results can be explained without requiring major differences in demographic parameters between males and females. The dependence of the partitioning on the number of individuals sampled from each region and on the number of markers used is discussed.

PMID:
15601537
[PubMed - indexed for MEDLINE]
PMCID:
PMC3525066
Free PMC Article

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