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J Virol. 2005 Jan;79(1):592-6.

Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.

Author information

  • 1Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan.

Abstract

The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations.

PMID:
15596851
[PubMed - indexed for MEDLINE]
PMCID:
PMC538706
Free PMC Article

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