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Microbes Infect. 2004 Dec;6(15):1361-7.

Endotoxin recognition and signal transduction by the TLR4/MD2-complex.

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  • 1Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, LRB, Room 308, 364 Plantation Street, Worcester, MA 01605, USA.

Abstract

Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.

PMID:
15596121
[PubMed - indexed for MEDLINE]
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