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1: J Pediatr Hematol Oncol. 2004 Dec;26(12):831-3. Links

Severe systemic autoimmune disease associated with Epstein-Barr virus infection.

Sevilla J, del Carmen Escudero M, Jiménez R, González-Vicent M, Manzanares J, García-Novo D, Madero L.

Pediatric Oncohematology, Hospital Niño Jesús, Menéndez Pelayo 65, Madrid 28009, Spain. jsevilla.hnjs@salud.madrid.org

Infection with Epstein-Barr virus (EBV) has been associated with different autoimmune manifestations. The authors describe a girl who developed a severe systemic autoimmune disease with severe autoimmune hemolytic anemia, mild autoimmune thrombopenia, antineutrophil antibodies, and fatal autoimmune hepatitis after EBV infection. Despite immunosuppressive treatment and ultimately liver transplantation, this patient could not overcome her clinical condition and died. The etiopathogenesis of this complex disease and the association with EBV infection is discussed.

PMID: 15591906 [PubMed - indexed for MEDLINE]

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