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    J Neuroimmunol. 2005 Jan;158(1-2):145-52.

    Modulation of the innate immune response to HSV-1 following acute administration of morphine: role of hypothalamo-pituitary-adrenal axis.

    Sheridan PA, Moynihan JA.

    Source

    Interdepartmental Program in Neuroscience, 575 Elmwood Ave., University of Rochester, Rochester, NY 14621, USA. patricia_sheridan@med.unc.edu

    Abstract

    A single injection of morphine significantly increased interferon (IFN)-beta and IFN-alpha mRNA in spleens from herpes simplex virus (HSV)-1 infected male Balb/cByJ mice. However, significant suppression of IFN-gamma and interleukin (IL)-12 production was observed in spleens from morphine-treated mice. Pretreatment with RU486 blocked morphine-induced increases in IFN-beta, and reversed the suppression of IFN-gamma. However, RU486 did not restore IFN-alpha or IL-12. The results suggest that a single exposure to morphine 4 h prior to infection can significantly alter innate immune responses to a viral pathogen, and that these effects are partially mediated by glucocorticoids.

    PMID:
    15589048
    [PubMed - indexed for MEDLINE]

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