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J Med Chem. 2004 Dec 16;47(26):6649-52.

Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates.

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  • 1Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.


Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.

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