Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bioinformatics. 2005 Apr 15;21(8):1389-92. Epub 2004 Dec 7.

LongSAGE analysis revealed the presence of a large number of novel antisense genes in the mouse genome.

Author information

  • 1Institute of Developmental Genetics, GSF-National Research Center for Environment and Health, Ingolst├Ądter Landstrasse 1, D-85764 Neuherberg, Germany.

Abstract

MOTIVATION:

Despite the increasing notions of the functional importance of antisense transcripts in gene regulation, the genome-wide overview on the ontology of antisense genes has not been obtained. Therefore, we tried to find novel antisense genes genome-wide by using our LongSAGE dataset of 202 015 tags (consisting of 41 718 unique tags), experimentally generated from mouse embryonic tail libraries.

RESULTS:

We identified 1260 potential antisense genes, of which 1001 are not annotated in EnsEMBL, thereby being regarded as novel. Interestingly their sense counterparts were co-expressed in the majority of the cases.

CONCLUSIONS:

The use of LongSAGE transcriptome data is extremely powerful in the identification of thus-far unknown antisense transcripts, even in the case of well-characterized organisms like the mouse.

CONTACT:

imai@gsf.de.

PMID:
15585522
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk