Your browser version may not work well with NCBI's Web applications. More information here...
1: Bioorg Med Chem Lett. 2005 Jan 3;15(1):115-9.Click here to read Links

Aminothiazole inhibitors of HCV RNA polymerase.

Shipps GW Jr, Deng Y, Wang T, Popovici-Muller J, Curran PJ, Rosner KE, Cooper AB, Girijavallabhan V, Butkiewicz N, Cable M.

NeoGenesis Pharmaceuticals Inc., Department of Chemistry, 840 Memorial Drive, Cambridge, MA 02139, USA. shipps@neogenesis.com

Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position. The composition of these compounds suggests that they may be interacting at a recently discovered allosteric site on the polymerase.

PMID: 15582422 [PubMed - indexed for MEDLINE]