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1: Bioorg Med Chem Lett. 2005 Jan 3;15(1):37-9.Click here to read Links

Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs.

Makarov VA, Riabova OB, Granik VG, Dahse HM, Stelzner A, Wutzler P, Schmidtke M.

Department of Medicinal Chemistry, Research Center for Antibiotics, 3a Nagatinskaya str., Moscow 117105, Russia.

A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical beta-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.

PMID: 15582406 [PubMed - indexed for MEDLINE]