Bioorg Med Chem Lett. 2005 Jan 3;15(1):29-35.

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.

Qiao JX, Cheng X, Modi DP, Rossi KA, Luettgen JM, Knabb RM, Jadhav PK, Wexler RR.

Source

Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. jennifer.qiao@bms.com

Abstract

Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.

PMID:: 15582405; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa. [Bioorg Med Chem. 2007]
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Kochanny MJ, Adler M, Ewing J, Griedel BD, Ho E, Karanjawala R, Lee W, Lentz D, Liang AM, Morrissey MM, et al. Bioorg Med Chem. 2007 Mar 1; 15(5):2127-46. Epub 2006 Dec 13.
SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa. [Bioorg Med Chem Lett. 2004]
SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa.
Smallheer JM, Alexander RS, Wang J, Wang S, Nakajima S, Rossi KA, Smallwood A, Barbera F, Burdick D, Luettgen JM, et al. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5263-7.
Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. [Bioorg Med Chem Lett. 2004]
Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa.
Mederski WW, Cezanne B, van Amsterdam C, Bühring KU, Dorsch D, Gleitz J, März J, Tsaklakidis C. Bioorg Med Chem Lett. 2004 Dec 6; 14(23):5817-22.
Review Recent advances in serine protease inhibitors as anticoagulant agents. [Curr Pharm Des. 2007]
Review Recent advances in serine protease inhibitors as anticoagulant agents.
Prezelj A, Anderluh PS, Peternel L, Urleb U. Curr Pharm Des. 2007; 13(3):287-312.
Review Dual inhibitors of the blood coagulation enzymes. [Curr Med Chem. 2004]
Review Dual inhibitors of the blood coagulation enzymes.
Kranjc A, Kikelj D. Curr Med Chem. 2004 Oct; 11(19):2535-47.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
BioAssay
PubChem BioAssay experiments on the biological activities of small molecules that cite the current articles. The depositors of BioAssay data provide these references.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.
5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.
Bioorg Med Chem Lett. 2005 Jan 3 ;15(1):29-35.

PubMed
The efficacy of continuous passive motion in the rehabilitation of anterior cruc...
The efficacy of continuous passive motion in the rehabilitation of anterior cruciate ligament reconstructions.
Am J Sports Med. 1992 Mar-Apr ;20(2):122-7.

PubMed
Effects of ozone on isolated peripheral blood mononuclear cells.
Effects of ozone on isolated peripheral blood mononuclear cells.
Toxicol In Vitro. 2005 Feb ;19(1):55-61.

PubMed
Excess risk thresholds in ultrasound safety studies: statistical methods for dat...
Excess risk thresholds in ultrasound safety studies: statistical methods for data on occurrence and size of lesions.
Ultrasound Med Biol. 2004 Oct ;30(10):1289-95.

PubMed
Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 ...
Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice.
Food Chem Toxicol. 2005 Jan ;43(1):1-19.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa.

Source

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Chemical Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information