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Nutrient sensing and metabolic decisions.

Author information

  • 1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84132-3201, USA. janet@biochem.utah.edu

Abstract

Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved from yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, mTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their similarities, differences and roles in disease.

PMID:
15581787
[PubMed - indexed for MEDLINE]
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