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J Pediatr. 2004 Dec;145(6):835-7.

Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy.

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  • 1Division of Newborn Services, Royal Women's Hospital, Neonatal Neurology, Royal Children's Hospital, Melbourne, Australia.


Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.

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