J Pediatr. 2004 Dec;145(6):835-7.

Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy.

Inder TE, Hunt RW, Morley CJ, Coleman L, Stewart M, Doyle LW, Jacobs SE.

Source

Division of Newborn Services, Royal Women's Hospital, Neonatal Neurology, Royal Children's Hospital, Melbourne, Australia. terrie.inder@rch.org.au

Abstract

Twenty-six infants with hypoxic-ischemic encephalopathy (HIE) were randomized to normothermia or to systemic hypothermia. The hypothermia group had less cortical gray matter signal abnormality on magnetic resonance imaging (MRI) (1/12 vs 7/14 infants in the normothermic group; P = .036), which may indicate differing regional benefit from systemic hypothermia.

Comment in

Brain protection for girls and boys. [J Pediatr. 2004]
Brain protection for girls and boys.Edwards D. J Pediatr. 2004 Dec; 145(6):723-4.

PMID:: 15580212; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. [Arch Pediatr Adolesc Med. 2012]
Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial.
Cheong JL, Coleman L, Hunt RW, Lee KJ, Doyle LW, Inder TE, Jacobs SE, Infant Cooling Evaluation Collaboration. Arch Pediatr Adolesc Med. 2012 Jul 1; 166(7):634-40.
Volumetric and anatomical MRI for hypoxic-ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments. [J Perinatol. 2009]
Volumetric and anatomical MRI for hypoxic-ischemic encephalopathy: relationship to hypothermia therapy and neurosensory impairments.
Parikh NA, Lasky RE, Garza CN, Bonfante-Mejia E, Shankaran S, Tyson JE. J Perinatol. 2009 Feb; 29(2):143-9. Epub 2008 Nov 20.
Systemic hypothermia in infants with hypoxic-ischaemic encephalopathy: a French pilot study. [Dev Med Child Neurol Suppl. 2001]
Systemic hypothermia in infants with hypoxic-ischaemic encephalopathy: a French pilot study.
Zupan V. Dev Med Child Neurol Suppl. 2001 Mar; 86:32.
Review Hypoxic ischemic encephalopathy and hypothermia: a critical look. [Obstet Gynecol. 2005]
Review Hypoxic ischemic encephalopathy and hypothermia: a critical look.
Higgins RD. Obstet Gynecol. 2005 Dec; 106(6):1385-7.
Review Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review. [Arch Pediatr Adolesc Med. 2007]
Review Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review.
Shah PS, Ohlsson A, Perlman M. Arch Pediatr Adolesc Med. 2007 Oct; 161(10):951-8.

See reviews... See all...

Cited by 13 PubMed Central articles

Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI). [BMC Pediatr. 2012]
Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI).
Filippi L, Fiorini P, Daniotti M, Catarzi S, Savelli S, Fonda C, Bartalena L, Boldrini A, Giampietri M, Scaramuzzo R, et al. BMC Pediatr. 2012 Sep 5; 12:144. Epub 2012 Sep 5.
Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy. [Neurology. 2012]
Impact of therapeutic hypothermia on MRI diffusion changes in neonatal encephalopathy.
Bednarek N, Mathur A, Inder T, Wilkinson J, Neil J, Shimony J. Neurology. 2012 May 1; 78(18):1420-7. Epub 2012 Apr 18.
Acute brain injury and therapeutic hypothermia in the PICU: A rehabilitation perspective. [J Pediatr Rehabil Med. 2009]
Acute brain injury and therapeutic hypothermia in the PICU: A rehabilitation perspective.
Fink EL, Beers SR, Russell ML, Bell MJ. J Pediatr Rehabil Med. 2009; 2(4):309-19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Randomized trial of systemic hypothermia selectively protects the cortex on MRI ...
Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy.
J Pediatr. 2004 Dec ;145(6):835-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: