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Immunogenetics. 2004 Dec;56(9):679-81. Epub 2004 Nov 11.

The EGF-TM7 family of the rat.

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  • 1Laboratory for Experimental Immunology, G1-106, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands.


EGF-TM7 receptors are adhesion class heptahelical molecules predominantly expressed by cells of the immune system. Based on an analysis of the recently unraveled genome, the EGF-TM7 family of the rat is described here. Like the mouse, the rat has three EGF-TM7 receptors--CD97, EMR1 and EMR4. The highest conservation between the orthologues lies within the membrane-spanning part and emphasizes the functional importance of this region.

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